A Clinical Trial of Oral Hyposensitization in Systemic Allergy to Nickel

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Nickel oral hyposensitization in patients with systemic nickel allergy syndrome

BACKGROUND This is the first randomized, double-blind, placebo-controlled trial (EUDRACT No. 2009-013923-43) evaluating nickel oral hyposensitizing treatment (NiOHT) in patients with "systemic nickel allergy syndrome" (SNAS), characterized by Ni-allergic contact dermatitis and systemic reactions after eating Ni-rich food. METHODS Adults with positive Ni-patch test, who reported symptoms sugge...

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Systemic nickel allergy syndrome

Methods Demonstrate SNAS which is characterized by contact dermatitis to nickel and systemic reactions after ingestion of rich foods nickel.We evaluated adult patients with ages between 18 and 65 years, positive patch test for nickel, grades 3 and 4, and who had symptoms suggestive of SNAS.These patients had eczematous lesions of contact dermatitis did not disappear. That even with the exclusio...

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Reply to: Update on systemic nickel allergy syndrome and diet.

I am glad to reply to Goldenberg and Jacob’s observations, whom I thank for the kind attention given to my article. As a preliminary consideration, I wish to reiterate that my paper discussed exclusively the exposure to nickel via food; it didn’t discuss the other routes of systemic exposure. It distinguished allergic contact dermatitis (ACD) from systemic nickel allergy syndrome (SNAS) and, wi...

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Nickel allergy in relationship to previous oral and cutaneous nickel contact.

Potential relationships between the development of nickel allergy and previous ear piercing or orthodontic treatment with nickel-containing appliances were studied in 294 patients. We found 77 (31.2%) of 247 patients with pierced ears were allergic to nickel compared to only three (6.4%) patients without pierced ears (p = 0.001), which confirms earlier suggestions that nickel allergy (as assess...

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ژورنال

عنوان ژورنال: International Journal of Immunopathology and Pharmacology

سال: 2006

ISSN: 2058-7384,2058-7384

DOI: 10.1177/039463200601900315